Pharma
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Cleaning Method Validation

Validation that equipment is free from API residues and detergents between production batches, as per FDA cGMP guidelines.

Cleaning ValidationcGMPSwabRinse
Overview

About This Service

AnalytiLab provides cleaning validation services to demonstrate that pharmaceutical manufacturing equipment is adequately cleaned between production batches. Our services include development and validation of analytical methods for swab and rinse samples, determination of acceptance limits, and preparation of cleaning validation protocols and reports per FDA cGMP and EMA guidelines.

FDA cGMP 21 CFR Part 211EMA Cleaning ValidationICH Q3APIC/S

Key Information

Turnaround Time15–25 working days
Sample TypesSwab, Rinse water, TOC
Regulatory AcceptanceUSFDA, EMA, PIC/S
DeliverableProtocol + Validation Report

Accredited by

NABLISO 17025USFDA
Scope of Work

What's Included

Swab sample analysis for API residues
Rinse water analysis (HPLC and TOC)
Acceptance limit calculation (MACO, 10 ppm, visual)
Cleaning validation protocol preparation
Analytical method development for cleaning
Detergent residue testing
Worst-case product identification
Recovery studies from equipment surfaces
Cleaning validation report preparation
FDA/EMA regulatory submission support
Equipment

Instruments Used

HPLC (UV/PDA)

API residue quantification in swab/rinse

TOC Analyzer

Total organic carbon in rinse water

UV-Vis Spectrophotometer

Rapid screening of API residues

ICP-OES

Detergent residue (phosphate) analysis

Compliance

Regulatory Standards

FDA cGMP 21 CFR Part 211
EMA Cleaning Validation
ICH Q3A
PIC/S
Our Process

How We Work

01

Limit Calculation

MACO and acceptance limits calculated based on therapeutic dose and batch size.

02

Method Development

Sensitive HPLC/TOC method developed and validated for swab/rinse matrices.

03

Recovery Studies

Swab recovery studies performed on representative equipment surfaces.

04

Validation Report

Full cleaning validation report with protocol, data, and compliance statement.

Get Started

Ready to Start Your Cleaning Method Validation?

Our scientific team is ready to assist. Submit your sample or request a quote today.