Special Studies
🔬

Extractable & Leachable (E&L) Studies

Assessment of drug-container interactions using LCMS/MS, GCMS, and ICPMS. 2000+ studies. Data accepted by US & EU regulators.

E&LLCMS/MSGCMSPackaging
Overview

About This Service

AnalytiLab is a specialized center for Extractable and Leachable (E&L) studies, having completed over 2,000 studies for pharmaceutical packaging systems. Our E&L studies assess the safety of drug-container closure interactions for parenteral, inhalation, ophthalmic, and oral dosage forms. Our data has been accepted by USFDA, EMA, and other global regulatory agencies.

USP <1663>USP <1664>ICH Q3EBioPhorumPQRI

Key Information

Studies Completed2,000+
Regulatory AcceptanceUSFDA, EMA, PMDA
Dosage FormsParenteral, Inhalation, Ophthalmic, Oral
Turnaround Time30–60 working days

Accredited by

NABLISO 17025USFDA
Scope of Work

What's Included

Extractables screening (organic and inorganic)
Leachables monitoring in drug product
Threshold of Toxicological Concern (TTC) assessment
Safety concern threshold (SCT) evaluation
Analytical evaluation threshold (AET) calculation
Container closure integrity testing
Packaging material characterization
Risk assessment and safety evaluation
Regulatory submission support (USFDA, EMA)
Studies for parenteral, inhalation, ophthalmic dosage forms
Equipment

Instruments Used

LCMS/MS (Triple Quadrupole)

Non-volatile organic extractables and leachables

GC-MS / GC-FID

Volatile and semi-volatile organic compounds

ICP-MS

Elemental extractables and leachables

ICP-OES

Multi-element screening of extractables

Compliance

Regulatory Standards

USP <1663>
USP <1664>
ICH Q3E
BioPhorum
PQRI
Our Process

How We Work

01

Scope & Risk Assessment

Packaging materials identified, risk assessment performed, AET and SCT calculated.

02

Extraction Studies

Controlled extraction using multiple solvents; exhaustive and simulated-use extractions.

03

Analytical Testing

LCMS/MS, GC-MS, ICP-MS screening; compound identification and quantification.

04

Safety Assessment & Report

TTC-based safety evaluation; comprehensive E&L report for regulatory submission.

Get Started

Ready to Start Your Extractable & Leachable (E&L) Studies?

Our scientific team is ready to assist. Submit your sample or request a quote today.