Chemical
⚛️

Elemental Impurity Testing

ICH Q3D-compliant testing of elemental impurities in APIs, drug products, and raw materials using ICP-OES and ICP-MS.

ICH Q3DICP-MSICP-OESMetals
Overview

About This Service

Our elemental impurity testing service provides ICH Q3D and USP <232>/<233> compliant analysis of 24 elemental impurities in pharmaceutical products. Using ICP-OES and ICP-MS with microwave digestion, we deliver accurate, sensitive, and regulatory-compliant results for APIs, drug products, excipients, and packaging materials.

ICH Q3DUSP <232>USP <233>EP 5.20JP

Key Information

Elements Tested24 ICH Q3D elements
Detection LimitSub-ppb (ICP-MS)
Turnaround Time7–10 working days
Regulatory AcceptanceUSFDA, EMA, ICH

Accredited by

NABLISO 17025USFDA
Scope of Work

What's Included

All 24 ICH Q3D elemental impurities
Class 1 elements: As, Cd, Hg, Pb
Class 2A elements: Co, Ni, V
Class 2B elements: Ag, Au, Ir, Os, Pd, Pt, Rh, Ru, Se, Tl
Class 3 elements: Ba, Cr, Cu, Li, Mo, Sb, Sn
Risk assessment support
Oral, parenteral, and inhalation PDEs
Excipient and raw material testing
Packaging material extractables
Method validation per USP <233>
Equipment

Instruments Used

ICP-MS

Trace elemental analysis at ppb/ppt levels

ICP-OES

Multi-element analysis at ppm levels

Microwave Digestion System

Sample preparation for metals analysis

AAS (Flame/Graphite Furnace)

Single element confirmation analysis

Compliance

Regulatory Standards

ICH Q3D
USP <232>
USP <233>
EP 5.20
JP
Our Process

How We Work

01

Risk Assessment

Elemental impurity risk assessment performed per ICH Q3D decision tree.

02

Sample Preparation

Microwave-assisted acid digestion with certified reference standards.

03

ICP-MS/OES Analysis

Multi-element analysis with internal standards for accuracy and precision.

04

PDE Comparison & Report

Results compared against PDEs; compliance statement and full report issued.

Get Started

Ready to Start Your Elemental Impurity Testing?

Our scientific team is ready to assist. Submit your sample or request a quote today.