Chemical
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Residual Solvent Testing

Headspace GC and direct injection GC methods for Class 1, 2, and 3 residual solvents in APIs and drug products.

USP <467>ICH Q3CHeadspace GCClass 1/2/3
Overview

About This Service

AnalytiLab provides ICH Q3C and USP <467> compliant residual solvent testing for APIs, drug products, and excipients. Using headspace GC-FID and GC-MS, we detect and quantify Class 1 (carcinogenic), Class 2 (non-genotoxic), and Class 3 (low toxic potential) solvents with high sensitivity and accuracy.

USP <467>ICH Q3CEP 2.4.24JP

Key Information

Turnaround Time5–7 working days
Solvents Covered60+ ICH Q3C solvents
Detection LimitSub-ppm levels
Regulatory AcceptanceUSFDA, EMA, ICH

Accredited by

NABLISO 17025USFDA
Scope of Work

What's Included

Class 1 solvents (benzene, CCl4, 1,2-DCE)
Class 2 solvents (acetonitrile, methanol, DCM)
Class 3 solvents (acetone, ethanol, IPA)
Headspace GC-FID (primary method)
GC-MS for unknown identification
Method development for novel solvents
Limit testing and quantitative analysis
ICH Q3C Option 1 and Option 2 limits
Pharmaceutical excipient testing
Regulatory submission-ready reports
Equipment

Instruments Used

GC-FID with Headspace Sampler

Primary method for residual solvents

GC-MS

Identification and confirmation of unknowns

Headspace Autosampler

Automated sample introduction

Static Headspace System

Volatile solvent analysis

Compliance

Regulatory Standards

USP <467>
ICH Q3C
EP 2.4.24
JP
Our Process

How We Work

01

Solvent Identification

Solvents used in synthesis identified; ICH Q3C class determined.

02

Method Selection

USP <467> method or validated in-house method selected.

03

Headspace GC Analysis

Samples analyzed by headspace GC-FID with certified reference standards.

04

Limit Comparison & Report

Results compared against ICH Q3C/USP <467> limits; compliance report issued.

Get Started

Ready to Start Your Residual Solvent Testing?

Our scientific team is ready to assist. Submit your sample or request a quote today.